National Heart, Lung, and Blood Institute Epithelial Systems Biology Laboratory

RECOn - Renal Epithelial Cell Ontology

Renal tubule cell nomenclature.
The scheme shows the connection of both a short-looped nephron and a long-looped nephron to the collecting duct system. The numbers point to different renal tubule segments and the cell types that they contain are listed on the right of the scheme. Dashed lines indicate regional boundaries. The cortico-medullary junction is defined by the arcuate arteries (not shown in this diagram). The division between the outer stripe and inner stripe of the outer medulla is defined by the transitions from proximal straight tubules (PST) to descending thin limbs (DTL1, DTL2, DTL3) of Henle's loops. The junction between the outer medulla and inner medulla is defined by the transitions from the ascending thin limbs (ATL) of Henle of the long-loop nephrons to the medullary thick ascending limbs (MTAL) of Henle's loops. The division between the cortical labyrinth and cortical medullary rays is indicated but not labeled.

Drawing based on that of the original Renal Commission of the International Union of Physiological Sciences (IUPS) publication. [Kriz W, Bankir L. A standard nomenclature for structures of the kidney. The Renal Commission of the International Union of Physiological Sciences (IUPS). Kidney Int. 1988 Jan;33(1):1-7. PubMed PMID: 3352156.]

To download the terms in a document click here.

Reference: Chen L, Clark JZ, Nelson JW, Kaissling B, Ellison DH, Knepper MA. Renal-Tubule Epithelial Cell Nomenclature for Single-Cell RNA-Sequencing Studies. Journal of the American Society of Nephrology 2019;30: 1358-1364.



This website was created by Jevin Z. Clark, Lihe Chen, and Mark Knepper. Contact us with questions or comments: knep@helix.nih.gov