The NIH HPC group plans, manages and supports
high-performance computing systems specifically for use by the
intramural NIH community. These systems include
Biowulf,
a 105,000+ processor
Linux cluster;
Helix, an interactive system for
file transfer and management, and
Helixweb, which provides a number of web-based
scientific tools. We provide access to a wide range of computational
applications for genomics, molecular and structural biology, mathematical and
graphical analysis, image analysis, and other scientific fields.
The continued growth and support of NIH's Biowulf cluster is dependent upon
its demonstrable value to the NIH Intramural Research Program. If you publish
research that involved significant use of Biowulf, please cite the cluster.
Suggested citation text:
This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).
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Biowulf Utilization
Wednesday, October 28th, 2026
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Last 24 hrs
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102,334 jobs submitted
80,532 jobs completed
1,821,097 CPU hrs used
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23 NIH Institutes
367 Principal Investigators
852 users
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Announcements
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Recent Papers that used Biowulf & HPC Resources
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Aberrant one-carbon metabolism and ancestral genetics underlie edematous severe acute malnutrition
Lie, NC; Han, Y; Li, Q et al.
Nat Commun
, DOI://10.1038/s41467-026-74239-x (2026)
A stem-like chromatin program in small-cell lung cancer is associated with poor outcomes after chemoimmunotherapy
Kumar, R; Desai, P; El Meskini, R et al.
Cell Rep Med
, DOI://10.1016/j.xcrm.2026.103027 (2026)
Ryder: epigenome normalization using a two-tier model and internal reference regions
Cao, Y; Ge, G; Zhao, K; ,
Bioinformatics
, DOI://10.1093/bioinformatics/btag753 (2026)
Utility of Pancreatic Perivascular Adipose Tissue as a CT Imaging Biomarker for Diagnosing Type 2 Diabetes
Prasad, AV; Mathai, TS; Balamuralikrishna, PTS et al.
Diabetes
, DOI://10.2337/db25-1140 (2026)
Daturolides A-K, cytotoxic sesquiterpene lactones from Datura wrightii
Hwang, JY; Wilson, BAP; Marron, L et al.
RSC Adv
, DOI://10.1039/d6ra08123a (2026)
Use of organ transplant solution to preserve skeletal muscle for cellular and spatial transcriptomic analyses
Uapinyoying, P; Moon, YJ; Zhang, A et al.
Sci Rep
, DOI://10.1038/s41598-026-58534-7 (2026)
Basal Marker ΔNp63α Is Enriched in Pancreatic Cancer Metastases but Not in Primary Tumors Post-Chemotherapy
Ryan, DH; Ohara, Y; Kruhlak, MJ et al.
Cancer Med
, DOI://10.1002/cam4.72322 (2026)
Generalist foundation models from a multimodal dataset for 3D computed tomography
Hamamci, IE; Er, S; Wang, C et al.
Nat Biomed Eng
, DOI://10.1038/s41551-025-01599-y (2026)
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