The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Tuesday, February 3rd, 2026
utilization graph
Last 24 hrs
89,550 jobs submitted
76,485 jobs completed
2,313,818 CPU hrs used
23 NIH Institutes
266 Principal Investigators
529 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6670 papers)

Linking subjective experience of anxiety to brain function using natural language processing
Kirk, PA; Qamar, P; Lentz, J et al.
Soc Cogn Affect Neurosci , DOI://10.1093/scan/nsaf099 (2026)


A quorum-sensing molecule from Pseudomonas aeruginosa induces defensive multicellularity in a coinfecting pathogen
Katharios-Lanwermeyer, S; Zarrella, TM; Godsil, M et al.
Proc Natl Acad Sci U S A , DOI://10.1073/pnas.2513122123 (2026)


Macrophages Mediate Mesoscale Brain Mechanical Homeostasis
So, WY; Johnson, B; Gordon, PB et al.
Adv Mater , DOI://10.1002/adma.202517493 (2026)


Mesoscopic analysis of GABAergic marker expression in acetylcholine neurons in the whole mouse brain
Goral, RO; Roy, S; Co, CA et al.
iScience , DOI://10.1016/j.isci.2025.114531 (2026)


Genetic contributions to Alzheimer's disease and frontotemporal dementia in admixed Latin American populations
Acosta-Uribe, J; Piña-Escudero, SD; Cochran, JN et al.
NPJ Dement , DOI://10.1038/s44400-025-00025-z (2026)


Heritability and Transcriptional Impact of JAK3, STAT5A and STAT6 Variants in a Tyrolean Family
Lee, HK; Haikarainen, T; Caf, Y et al.
Int J Mol Sci , DOI://10.3390/ijms27020913 (2026)


thumbnail image from paper LDB1 regulates gene expression and chromatin structure in pluripotency and lineage differentiation
Kwon, H; Kim, J; Zhou, L; Dean, A; ,
Nucleic Acids Res , DOI://10.1093/nar/gkag064 (2026)


Sequential Event Rate Monitoring
Kim, DY; Han, SM; ,
Stat Med , DOI://10.1002/sim.70359 (2026)