The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Sunday, October 5th, 2025
utilization graph
Last 24 hrs
18,554 jobs submitted
12,926 jobs completed
2,019,444 CPU hrs used
23 NIH Institutes
156 Principal Investigators
266 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6518 papers)

Y665F variant of mouse Stat5b protects against acute kidney injury through transcriptomic shifts in renal gene expression
Jankowski, J; Lee, HK; Hennighausen, L; ,
Sci Rep , DOI://10.1038/s41598-025-15812-0 (2025)


Ocular immune privilege in action: The living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells
Peng, Z; Nagarajan, V; Horai, R et al.
Cell Rep , DOI://10.1016/j.celrep.2025.115780 (2025)


Sentence-Aligned Simplification of Biomedical Abstracts
Ondov, B; Demner-Fushman, D; ,
Artif Intell Med Conf Artif Intell Med (2005-) , DOI://10.1007/978-3-031-66538-7_32 (2024)


Multiplexed Nanoscale Viscoelastic Mapping at Multiple Time Scales of Melanoma Cells as a Label-Free Cancer Biomarker
Parvini, C; Massey, A; Mezher, M; Cartagena-Rivera, AX; ,
ACS Nano , DOI://10.1021/acsnano.5c01873 (2025)


Structural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance
Agostini, L; Pfister, JA; Basnet, N et al.
Nat Commun , DOI://10.1038/s41467-025-62696-9 (2025)


Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries
Khani, M; Akçimen, F; Grant, SM et al.
Nat Commun , DOI://10.1038/s41467-025-62108-y (2025)


Genetic background and oncogenic driver determines the genomic evolution and transcriptomics of mammary tumor metastasis
Ross, CR; Szczepanek, K; Sanford, J et al.
Commun Biol , DOI://10.1038/s42003-025-08624-5 (2025)


A highly conserved sRNA downregulates multiple genes, including a σ54 transcriptional activator, in the virulence mode of Bordetella pertussis
Sim, M; Nguyen, J; Škopová, K et al.
mBio , DOI://10.1128/mbio.01356-25 (2025)