The NIH HPC group plans, manages and supports high-performance computing systems specifically for use by the intramural NIH community. These systems include Biowulf, a 105,000+ processor Linux cluster; Helix, an interactive system for file transfer and management, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

The continued growth and support of NIH's Biowulf cluster is dependent upon its demonstrable value to the NIH Intramural Research Program. If you publish research that involved significant use of Biowulf, please cite the cluster. Suggested citation text:

This work utilized the computational resources of the NIH HPC Biowulf cluster (https://hpc.nih.gov).

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Biowulf Utilization
Saturday, November 15th, 2025
utilization graph
Last 24 hrs
99,174 jobs submitted
86,556 jobs completed
2,283,043 CPU hrs used
22 NIH Institutes
295 Principal Investigators
578 users

Announcements
(All)
Recent Papers that used Biowulf & HPC Resources
(All 6582 papers)

Loss of paired immunoglobin-like type 2 receptor B gene associated with age-related macular degeneration impairs photoreceptor function in mouse retina
Dey, PN; Singh, N; Zelinger, L et al.
Hum Mol Genet , DOI://10.1093/hmg/ddae161 (2025)


ANTXR1 blockade enhances cardiac function in preclinical models of heart failure
Boccella, N; Yu, G; Seaman, S et al.
Nat Cardiovasc Res , DOI://10.1038/s44161-025-00725-y (2025)


thumbnail image from paper Single-fibril Förster resonance energy transfer imaging and deep learning reveal concentration dependence of amyloid β 42 aggregation pathways
Sohail, SH; Yoo, J; Chung, HS; ,
PNAS Nexus , DOI://10.1093/pnasnexus/pgaf342 (2025)


Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome
Das, SK; Karmakar, S; Venkatachalapathy, H et al.
Mol Cell , DOI://10.1016/j.molcel.2024.10.006 (2024)


Expanded Functionality and Portability for the Colvars Library
Fiorin, G; Marinelli, F; Forrest, LR et al.
J Phys Chem B , DOI://10.1021/acs.jpcb.4c05604 (2024)


Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins
Han, W; Yuan, B; Fan, X et al.
Nat Commun , DOI://10.1038/s41467-025-64748-6 (2025)


Adipocyte death promotes hepatic infiltration of S100A8+ macrophages and steatotic liver disease progression in mice
Guan, Y; Kim, Y; Wang, Y et al.
J Clin Invest , DOI://10.1172/JCI190635 (2025)


Analysis of a Novel Human Protein, ORF3, Encoded by Spacer rDNA
Chen, Y; Kim, JH; Lee, HS et al.
J Mol Evol , DOI://10.1007/s00239-025-10269-1 (2025)